FRG™ KO Mouse Models

 

C57Bl/6

 

The FRG™ KO on C57Bl/6 background was originally reported by Azuma et. al. in 2007.  Since then it has become a staple model for liver humanization and is well suited for studies in infectious disease, drug metabolism, toxicology, and cancer biology.  The animals weigh 25 grams on average and have a typical lifespan of 18-24 months.  Engraftment is sustained over the life of the animal with an appropriate regimen of CuRx™ Nitisinone (20-0026).

 

These pathogen-free animals are available as repopulated models with either human, C57Bl/6, or ROSA hepatocytes and can be purchased for use in your facility or as part of a study run at Yecuris™ facilities.  Breeding colonies are available under license from Yecuris™.  List prices serve as base price for the models and are subject to change depending on customer requirements.  Collaborator pricing is available.  If you are interested in purchasing animals or setting up your own colony, please contact us at info@yecuris.com.

Yecuris is fully equipped to run metabolism and toxicology studies with both labeled and unlabeled compounds.  Our metabolic caging can be used for studies that require single animal isolation.

Model	List Price	Catalog Number
FRG™ KO on C57Bl/6 – Human Repopulated, < 40%	$2000	10-0004
FRG™ KO on C57Bl/6 – Human Repopulated, < 40-70%	$2500	10-0005
FRG™ KO on C57Bl/6 – Human Repopulated, 70%+	$3500	10-0006
FRG™ KO on C57Bl/6 – C57Bl/6 Repopulated, 95%+	$1000	10-0002
FRG™ KO on C57Bl/6 – ROSA Repopulated, 95%+	$1750	10-0003
FRG™ KO on C57Bl/6 – Non-Repopulated	$500	10-0001

Non-Obese Diabetic (NOD)

 

Our next generation model, the FRG™ KO on the NOD background was developed to promote the engraftment of both liver and hematopoietic systems.  We currently offer these animals as liver repopulated models only and are optimizing the dual system for commercial launch.  The animals weigh 33 grams on average and have a typical lifespan of 18-24 months.  Engraftment is sustained over the life of the animal with an appropriate regimen of CuRx™ Nitisinone (20-0026).

Model	List Price	Catalog Number
FRG™ KO on NOD – Human Repopulated, < 40%	$2000	10-0011
FRG™ KO on NOD – Human Repopulated, < 40-70%	$2500	10-0012
FRG™ KO on NOD – Human Repopulated, 70%+	$3500	10-0013
FRG™ KO on NOD – NOD Repopulated, 95%+	$1000	10-0009
FRG™ KO on NOD – ROSA Repopulated, 95%+	$1750	10-0010
FRG™ KO on NOD – Non-Repopulated	$500	10-0008
FRG™ KO on NOD – Human Liver/Immune Repopulated	N/A	10-0015

Need help selecting which model is right for you?  Visit our Model Selection post to get basic information on animal choice and usage.